Blocking of FGFR signaling inhibits breast cancer cell proliferation through downregulation of D-type cyclins
نویسندگان
چکیده
منابع مشابه
Covalent Targeting of Fgfr/integrin Signaling Inhibits Breast Cancer Metastasis
Cell and molecular biology of breast cancer Faculty abstract(s) 3-4 Cell and molecular biology of breast cancer Graduate Student abstract(s) 5-9 Cell and molecular biology of breast cancer Post-Doctoral/Medical Fellow abstract(s) 10-12 Cell and molecular biology of breast cancer Research Technician abstract(s) 13 Novel modalities or technologies for breast cancer diagnosis and treatment Faculty...
متن کاملshRNA-mediated downregulation of α-N-Acetylgalactosaminidase inhibits migration and invasion of cancer cell lines
Objective(s): Extracellular matrix (ECM) is composed of many kinds of glycoproteins containing glycosaminoglycans (GAGs) moiety. The research was conducted based on the N-Acetylgalactosamine (GalNAc) degradation of ECM components by α-N-acetylgalactosaminidase (Nagalase) which facilitates migration and invasion of cancer cells. This study aims to investigate the effects of Naga-shRNA downregula...
متن کاملICA512 signaling enhances pancreatic beta-cell proliferation by regulating cyclins D through STATs.
Changes in metabolic demands dynamically regulate the total mass of adult pancreatic beta-cells to adjust insulin secretion and preserve glucose homeostasis. Glucose itself is a major regulator of beta-cell proliferation by inducing insulin secretion and activating beta-cell insulin receptors. Here, we show that islet cell autoantigen 512 (ICA512)/IA-2, an intrinsic tyrosine phosphatase-like pr...
متن کاملMicroRNA-802 suppresses breast cancer proliferation through downregulation of FoxM1.
An increasing number of studies have shown that microRNAs (miRNAs) are critical in tumor cell proliferation, as they modulate key gene transcripts. In the present study, the expression and roles of miRNA (miR)‑802 were analyzed by quantitative polymerase chain reaction in breast cancer cells. The results showed that expression levels of miR‑802 were significantly reduced in breast cancer tissue...
متن کاملCurcumin inhibits LPS-induced EMT through downregulation of NF-κB-Snail signaling in breast cancer cells.
Epithelial-mesenchymal transition (EMT) is considered a critical event in cancer cell invasion and metastasis. Emerging evidence has shown that curcumin may prevent or delay the progression of cancer, an effect that may be partially due to its ability to disrupt EMT, yet this has not yet been demonstrated. In this study, we used lipopolysaccharide...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncogene
سال: 2004
ISSN: 0950-9232,1476-5594
DOI: 10.1038/sj.onc.1207331